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found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses

L., Baronowsky, E

Transcription of nuclear-encoded genes related to mitochondrial function The nuclear genome encodes the majority of proteins required for mitochondrial function, and its epigenetic status profoundly influences mitochondrial biology

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Safety is ensured through medical screening before treatment initiation, sterile injection techniques and single-use equipment, ongoing patient monitoring throughout treatment, and immediate access to emergency medical protocols