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The difference in bioactivity may be related to the number of double bonds

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These limitations contribute to substantial morbidity, particularly in generalized and hypertrophic DLE subtypes that are often recalcitrant to treatment

For autoimmune patients who benefit metabolically from tirzepatide, planning pregnancy requires coordinated timing between optimizing body weight and metabolic health, ensuring autoimmune disease is in remission or well-controlled, washing out tirzepatide with adequate lead time, and transitioning to pregnancy-safe autoimmune medications