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Although cytokines are mainly produced by the immune system, there is also an unclear link between neuroinflammation and these peripheral proinflammatory cytokines (46) and some cytokines may also be produced in the CNS (201)

Acta Biochim Pol 50:31936 Zhang D, Lu H, Li J, Shi X, Huang C (2006) Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B

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Strikingly, higher SFB levels, as observed in MyD88 (an adaptor for different innate immune receptors which recognize microbial stimuli)-deficient mice models, protect mice of a diabetic genotype from the development of the disease, showing that the microbiota can exert both inhibiting and promoting effects [10]

doi: 10.1016/j.ecoenv.2023.114889 99 WangHHaoWYangLLiTZhaoCYanPet al

Islet beta-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model