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Its course is not as predictable as hematologic response, but most studies show little advantage of more intensive cobalamin treatment

Side effects to tell your doctor about immediately are skin rashes, itching, hives, swelling of the tongue, lips, or face, blueish skin, chest tightness or pain, trouble breathing, wheezing, dizziness, or red, swollen, painful area on a leg (via the Cleveland Clinic)

Additionally, in order to eliminate bias, both investigators and participants should be blinded and remain unaware of whether a participant is receiving a placebo or treatment