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Furthermore, ATF4, under conditions of stress, has been observed to interact with mTORC, thereby influencing cell survival

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It enables the intracellular degradation and recycling of damaged or redundant organelles and proteins, mainly through autophagosome formation and lysosomal degradation, serving dual roles in both physiological maintenance and pathological adaptation (Levine and Kroemer, 2019

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This consideration affects protocol design and subject selection in research settings

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Lemoine P, et al

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Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats

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