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These types of models are commonly used to investigate how signaling molecules influence coordinated repair responses rather than isolated cellular processes

We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-, interleukin-5 and 17, and interferon-), activity of NF-B and JNK pathways, and Hsp90 expression in immune cells

All counts were performed by two observers on two neighboring sections of each brain and the numbers averaged to a single data point depicted in the bar diagrams

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