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A significant inhibition of Nrf2 mRNA expression in NAC-treated rats supports this assumption, as in the absence of oxidative stress, Nrf2 expression was not activated

The most common adverse events are gastrointestinal: nausea (occurring in 12-33% of subjects depending on dose), diarrhea, constipation, and decreased appetite

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Randomization was conducted by an independent researcher who was not involved in patient enrollment, treatment administration, or outcome evaluation, ensuring allocation concealment

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