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The infection of the lungs can also indirectly increase the systemic pro-inflammatory factors and decrease oxygen levels, which induce intestinal inflammation, epithelial destruction, and antimicrobial peptide reduction, resulting in gut dysbiosis (Rastogi et al., 2022)

RRx-001, a small molecule which promotes the generation of nitric oxide in low-oxygen conditions, was given concurrently with whole-brain radiotherapy to 29 patients with BM, with melanoma and NSCLC as the most common primary tumor types

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