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The fragment corresponds to amino acid positions 176 to 191 of hGH and was identified as the region of the GH molecule responsible for its lipolytic fat-metabolising activity, separate from the anabolic and growth-promoting effects mediated by the GH receptor binding domains at the N-terminal end of the full molecule

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Neuropsychiatric symptoms such as depression, memory impairment, irritability, or cognitive decline may occur, making diagnosis challenging