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Keywords: cardiovascular diseases, glutathione, reactive oxygen species, reactive nitrogen species, oxidative stress 1

Cagrilintide monotherapy produced 10.8% mean body weight reduction at 26 weeks in the REWIND Phase 2 trial, while survodutide achieved 12.9% reduction at the highest evaluated dose (4.8mg weekly) in Phase 2 studies

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Together, this framework enables a comprehensive assessment of disease status, identification of vulnerable or high-risk phenotypes, and implementation of risk-adapted management strategies