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Cellular iron homeostasis also depends on iron regulatory proteins and iron-responsive elements (36)

Studies have demonstrated that although antibiotics do not play a significant role in treating UC in all trails, broad-spectrum oral antibiotic cocktails have reported a possible role in acute severe colitis and chronic persistent UC [153,154,155,156] .However, a systematic review of 12 randomized controlled trials (RCTs, include 847 participants) reported that no difference between antibiotics and placebo in the proportion of patients in clinical remission at the end of the intervention period [157]

In this context, classical results have shown that LA is endowed with antioxidant properties that are protective in the spleen against the deleterious actions of Gram-negative bacterial endotoxin [144]

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Polynucleotide, the active component in Rejuran S, promotes collagen and elastin production thus providing a direct skin-healing effect

Recent studies pointed out the role of bacteriophages and the virome in IBD pathogenesis