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Description

PMID 15598662

Both of these processes are mainly regulated by the signaling pathway: insulin-like growth factor-1 (IGF-1) phosphoinositide-3-kinase (PI3K) protein kinase B (Akt) mammalian target of rapamycin (mTOR)

Pathophysiological and therapeutical aspects

It has been demonstrated in mice with adipocytes deficient in mitochondrial transcription factor A that isolated mitochondrial dysfunction in adipose tissue can cause lipodystrophy and lead to MS and chronic inflammation (Vernochet et al., 2014)