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They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker H2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver

This evaluation was conducted using a holistic approach to establish a scientific basis for the review

May be administered several times a week

doi: 10.1016/j.neulet.2022.137015, 35 YamamotoM.KenslerT

Both HO-1 and its upstream regulator, nuclear factor erythroid 2-related factor 2 (Nrf2), are oxidative stress inhibitors (98100)