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Lancet 392, 22992312

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Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS, Life-Threatening Respiratory Depression)

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimers disease

Cohen, A

Although none of these approaches has so far provided conclusive evidence for disease-modifying efficacy, 3 target areas have progressed to phase 3 trials with signals for efficacy in some of these studies