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doi: 10.1016/j.neulet.2011.05.027

It is a co-factor for methionine synthase, an enzyme involved in the methylation cycle, which is crucial for the metabolism of amino acids and the production of neurotransmitters

Molecules 26(19):6076

They exist, but nowhere near on the same scale as those two games, and this is especially the case for very early Yu-Gi-Oh where such cards were exceptionally rare