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NE is also involved in regulating attention [86], in particular those related to emotional and neutral emotions [87], and this signalling network has been found altered in different brain areas in patients with ADHD [88]

Supporting this model, peripheral blood mononuclear cells from women with chronic pelvic pain release significantly greater amounts of IL-1 following lipopolysaccharide-induced TLR4 activation, compared with pain-free controls, indicating a state of peripheral immune hyper-responsiveness and systemic neuroimmune sensitization ( versus ectopic tissue implantation (Tsamantioti and Mahdy, 2025), both disorders exhibit abnormal endometrial progesterone signaling and chronic inflammatory signaling that may converge on a shared neuroimmune axis driving pelvic pain ( 4.5 Oxidative stress and pain sensitization There is growing evidence that oxidative stress may be involved in the multifactorial pathophysiology of PCOS, as it can synergize with heightened levels of basal proinflammatory signaling molecules to worsen the disease (Zeber-Lubecka et al., 2023)

Desorption electrospray ionization mass spectrometry (DESI-MS), which mainly shows lipid distribution, was applied in TC metastasis imaging displayed high signals of ceramides and glycerophosphoinisitols in TC metastasis [253]

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However, contradictory results reported by different groups, which may arise in part due to methodological differences, make an evaluation of the literature on alterations in brain GSH levels in human diseases difficult (Bottino et al