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In the macula of the human eye the pi class member GST P1-1 has more recently been found to be a high-affinity zeaxanthin-binding protein ( A completely different binding function was uncovered when GST of the pi class was found to be an endogenous inhibitor of Jun N-terminal kinase (JNK), thereby contributing to regulation of a protein kinase responsive to cellular stress ( In addition to the dimeric cytosolic GSTs, which are in focus in the present article, trimeric membrane-associated GST proteins, have also been identified

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Understanding the entire metabolic network and the factors that influence it is challenging