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The paradoxical effect of PARP inhibitor BGP-15 on irinotecan-induced cachexia and skeletal muscle dysfunction

Researchers also point out that a seven-amino acid synthetic peptide based on the actin-binding part of TB4 was able to promote repair in the aged animals comparable to that observed with the parent molecule. The amino acid sequence noted was LKKTETQ TB-500 without the N-terminal acetylation.26 November 2011 review In a review of TB4s basic properties and clinical applications, researchers dub it a regenerative peptide due to its role in repairing injured cells and tissues

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International Journal of Laboratory Hematology, 31: 18

In theory, there is no direct pharmacological conflict between these pathways