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A randomised, double-blind, placebo-controlled trial is the highest-quality study design for a single trial

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This was exemplifi ed by the fact that urinary excretion of methylcobalamin was one-third less that of cyanocobalamin.[1] Another point of interest regarding B12 supplementation is the commonly held belief that intramuscular injections of B12 are more effective than oral supplementation

To help bypass any barriers to absorption in the GI tract, many healthcare providers recommend B12 injections for deficiency, but research shows that very high doses of oral B12 (1,000 to 2,000 mcg once a day) can normalize serum B12 levels to a similar extent with minimal side effects