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Comorbidities and systemic inflammation Psoriasis is now increasingly recognized as a systemic inflammatory rather than an exclusively dermatological condition

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& Lee, S.-H

The peptide is unique among neuropeptides in several respects: it does not conform to typical neuropeptide structural motifs, its distribution in the brain and periphery differs from classical sleep-promoting substances, and it appears to exert effects through multiple pathways rather than through a single characterized receptor system