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Persistently high levels of ROS lead to oxidative stress, cellular damage, dysfunction, and even cell death [181]

The NF-B pathway regulates various factors upstream and downstream, further mediating the inflammatory response, oxidative stress response, liver fibrosis, cell apoptosis, autophagy and pyroptosis of liver tissue to promote the process of MASLD (384)

Nsairat H, Mahmoud IS, Odeh F, Abuarqoub D, Al-Azzawi H, Zaza R, et al

Co-transplantation of MSC in the treatment of PD Pereira et al

Open Acc J Envi Soil Sci

While only a small fraction of -syn (~4%) is phosphorylated in healthy brains, substantial accumulation of pS129 (~90%) is observed in brains with Lewy pathology, implicating a potentially important association between this posttranslational modification and the accumulation of -syn aggregates concomitant with LB formation and neurodegeneration (Fujiwara et al., 2002