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Apart from its role in the immune system, NADPH is required by the enzyme glutathione reductase to regenerate reduced glutathione, a key endogenous antioxidant that protects cells from oxidative stress [13]

Autopsies performed on individuals who died from causes other than thyroid cancer have revealed small PTCs in about 10% of cases, and this frequency has not changed since the 1970s

Notably, nutrient deprivation-induced ERS also influences the tumor immune microenvironment, transmitting regulatory signals via exosomes and other carriers to suppress T-cell function and promote the polarization of immunosuppressive M2-type macrophages [24]

Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)

The PML/RAR oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

Park SM