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Together, these results support that Cys180 is the critical residue that MeCbl directly coordinates to GSDME, thereby inhibiting GSDME-mediated pyroptosis

26MakinAJ, WendonJ, WilliamsR

Li, J., Xue, K., Zheng, Y., Wang, Y

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Normal iron homeostasis requires the transporter SLC48A1 for efficient heme-iron recycling in mammals

Glutathione and Amino Acid Metabolism The mechanism of aberrant amino acid metabolism in inducing ferroptosis is indicated as such: the system Xc on the cell membrane consists of a glycosylated heavy chain SLC3A2 and a non-glycosylated light chain SLC7A11, which can exchange extracellular cystine and intracellular glutamate (Glu) in a 1:1 ratio (Yang et al