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Ferroptosis is defined by excessive intracellular iron accumulation due to metabolic imbalance, where Fe 2+ generates a large amount of hydroxyl radicals (OH) through the Fenton reaction (Figure 2)

VRU 2005

Therefore, the strong immune response generated by peripheral immune organs may prevent tumors by eliciting a specific immune memory post-treatment with HMPB-H@M1EV + L