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Description

Insulin-like growth factor 1 receptor (IGF1R) was reported to affect the TME

Free Fe 2+ in cells causes lipid peroxidation via the Fenton reaction, the classic ferroptosis pathway

Despite a comprehensive understanding of two main mitochondrial pathways, intrinsic apoptosis and mitochondrial permeability transition (mPT)-driven necrosis, in acute and chronic degenerative diseases, the development of an effective therapeutic strategy remains a major challenge 2,3