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doi: 10.3390/pharmaceutics16121625 192 ZhangXWangSTangKPanWXuHLiYet al

Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine

It was also reported that icariin and irisin protect against myocardial and lung injury, respectively, by suppressing H/R-induced ferroptosis of cardiomyocytes and lung epithelial cells via activating Nrf2/HO-1 signaling [161,162]

Current research focuses on counteracting HO-1-mediated ferroptosis through the following strategies: using HO-1 inhibitors (e.g., zinc protoporphyrin-IX (ZnPP)), ferroptosis inhibitors (e.g., ferrostatin-1, iron chelators), modulating key signaling pathways (e.g., targeting the Nrf2/Keap1 axis), and microRNA-mediated inhibition (e.g., miR-24, miR-200c) (69)