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However, in another study, acetyl-l-carnitine therapy (50 mg/kg, i.p., 6 weeks) positively impacted the regeneration of unmyelinated fibres in the sciatic nerve based on a stereological analysis of myelinated/unmyelinated axon numbers, surface area, myelin thickness, and the myelin thickness-to-axon diameter ratio [45]

Finally, in order to prevent the rebound effect of glutaminase, glutamine is conjugated with phenylacetate to form phenylacetylglutamine, a molecule that cannot be metabolized and is harmlessly excreted in the urine [74]

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This review highlights the role of individual mGlu receptor subtypes in the pathophysiology of motor and non-motor symptoms of PD and in mechanisms that contribute to the progression of the disease