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Regarding safety, a recent literature review of double-blinded RCTs examined the safety and toxicity profiles of turmeric and curcumin in medical applications (237)

Figure 2 Numerous studies have highlighted the significance of oxidative stress and reduced GSH levels as major risk factors for neurodegenerative lesions in the central nervous system (CNS) across various neurological diseases (Dringen, 2000)

References 1 AbasubongK

After 10 weeks, the high-dose group exhibited significantly higher urate levels, joint deformities, synovial fluid crystal formation, and varying degrees of kidney damage

Measuring satellite signals are useful to control for change of total metabolite concentration throughout the infusion, a process that cannot be assessed by solely inferring the metabolite labelling from the drop of the initial H-C signal

Meister, Biochemistry 10 (3), 372 (1971)