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Glutathione reduction is a significant factor in initiating ferroptosis, a type of controlled cell death

Our findings align with previous studies with radical trapping antioxidants, i.e., ferrostatin-1 and liproxstatin-1, in MASLD models

There is no reaction in glycolysis in which carbon dioxide is produced, and this suggests that there must be some other pathway of glucose metabolism in the erythrocyte, in which carbon-1 of glucose is released as carbon dioxide

10.1038/s41422-020-0282-0 89

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Research on the role of macrophages in myocarditis has focused primarily on the M1 and M2 polarization phenotypes, with a general consensus that M1 macrophages exacerbate myocarditis, whereas M2 macrophages alleviate myocardial inflammation