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In the first month, some patients may experience subtle improvements increased energy, better focus, or modest changes in body composition

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This is why a personalized approach is so important

NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT

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5-Amino-1MQ has a half-life of 46 hours, so NNMT inhibition returns to baseline within 2436 hours of the last dose