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For example, one of the first postbiotic compounds described with potent anti-pathogenic activity was reuterin, produced by Lactobacillus reuteri

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The guidelines also point out their appropriate use in patients who were successfully treated previously with an MAOI and would like to resume therapy.30 Among the preferred uses of the classical MAOIs are the treatment of atypical depression, treatment-refractory patients, patients without compliance problems, and those with associated panic attacks.31 The MAOIs should be started at a low dose and titrated upward to the usual daily dosage (Table 3).24,30 Minimizing Safety and Tolerability Concerns Use of oral MAOIs is most commonly associated with early side effects such as insomnia, sedation, orthostatic hypotension, dizziness, and nausea, while later side effects often include weight gain, edema, muscle pain, myoclonus, paresthesia, and sexual dysfunction.24,32 Hypertensive crisis and serotonin syndrome (commonly related to medication nonadherence, dietary violations, or unwanted drug-drug interactions), both of which can occur as a result of the mechanism of action of MAOIs, are much more serious.24,29 Hypertensive crisis

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