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In the study by Fusi et al

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Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways

Temporary Fatigue A small percentage of users report experiencing mild fatigue or lightheadedness, in the first few days of use

The primary mechanism involves copper delivery to dermal tissues where this essential cofactor supports numerous enzymatic processes including collagen synthesis, elastin production, glycosaminoglycan formation, and antioxidant enzyme activation

Long-term systemic use is concerning for copper balance, as copper deficiency has been linked to neurodegenerative disorders and even excess copper is risky