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Mutations in several PD-related genes have been linked to autophagic deficits in neurons, including SNCA , LRRK2 , PARK7/DJ-1 , and VPS35 138,139,140,141

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Recently it has been shown that human umbilical vein endothelial cells (HUVEC) stimulated by the physiological mediator angiotensin II, generate and release 2 predominantly via an NADPH oxidase pathway and overproduction of 2 evokes oxidative stress in HUVEC