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NAC contains a free thiol group capable of breaking the stubborn disulfide bonds that hold microclots together

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Additionally, natural compounds [e.g., icariin II (234) and lycorine (241)] lack clear molecular targets: their direct binding partners or upstream signaling pathways (e.g., epigenetic regulators and kinase cascades) that modulate ferroptosis are poorly defined, hindering the optimization of potency and selectivity