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p value = 1.34E-04) and a nominally significant decrease in de novo PD vs

Transgenic mice overexpressing intestinal Cldn1 have been used to demonstrate consequent induction of MMP9 and pERK signalling and Notch-signalling pathway activation, leading to inhibition of goblet cell differentiation, decreased Muc2 expression and resultant mucosal inflammation (96)

doi: 10.1016/j.ijscr.2025.111179 Betsalel Adout , Imad Karam , Kafi Thomas , Sayed Ali , Aye M Thida , Sayra Ilyas , Rachelle Hamadi , Shoushtari Alavi , Maksim Agaronov , Edwin Chiu

High-Dose Vitamin C Infusions: Frequently used as an alternative supportive oncology strategy or a powerful antiviral and immune booster, the pro-oxidant tumor-disrupting benefits of high-dose vitamin C are heavily enhanced when paired with hyperbaric oxygen