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Unlike most targeted therapies, which act by inhibiting their target, a p53-targeted therapy must reactivate the protein, restoring its wild-type (WT)-like activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 91

Slowly titrating the dose over months allows the body to clear the toxic burden without triggering a massive immune flare or severe Herxheimer reaction

Additionally, survival rates for PCa patients significantly vary with age

Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study

The hepatopancreas of shrimp in the group HL displayed a notable elevation in TG content compared to group CON, whereas the expression of the fas gene was markedly downregulated