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The ADG of the animals that were selected was positive, and the litter origin of animals selected in each block was equal

Additionally, oxPTM-INS-Ab were detectable prior to clinical onset, identifying children at risk of progressing to clinical T1D (94)

These included a mitochondrial subtype, which is associated with a more favourable clinical outcome and is sensitive to inhibitors of oxidative phosphorylation, and a glycolytic, plurimetabolic subtype that is resistant to multiple treatment types 5