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As a single transmembrane receptor, the low-density lipoprotein receptor (LDLR) plays an important role in maintaining the homeostasis of intracellular cholesterol metabolism, in which exogenous cholesterol is internalized into the low-density lipoprotein (LDL) and taken up by the cell after binding to the LDLR on the cytosolic membrane [198]

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Based on the literature and the experimental design of this study, the AAV9 serotype used here has a demonstrated advantage in cardiac-specific transduction

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