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endocytosis and/or transcytosis of GSH transporter-targeted ligands may be assayed by in vivo bioimaging techniques using for instance near-infrared dyes or radioactive labels conjugated thereto, resulting in at least 10, 20, or 50% enhanced retention in CNS area of the ligand at given time-points (based on region of interest (ROI) pixel quantification), as compared to appropriate control conditions (e.g., comparison to reference compounds lacking GSH moieties)

Investigating the effects of cesarean delivery and antibiotic use in early childhood on risk of later attention deficit hyperactivity disorder

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H 2 O 2 -dependent signaling changes to these regulatory enzymes are known to impair cellular glucose uptake, thus contributing to onset and progression of diabetes as well as neurological disorders [65, 66]

Each pixel was transformed into a phasor plot according to the following equations: in which g i , j ( ) and s i , j ( ) are the x and y coordinates of the phasor plot, n and are the harmonic frequency and the angular frequency of excitation, respectively, and T is the repeat frequency of the acquisition

A previous study demonstrated that Flavonifractor plautii treatment calmed antigen-stimulated Th2 immune responses, consequently restraining interleukin (IL)-4 and ovalbumin-specific IgE production in ovalbumin-sensitized mice (48)