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Lipid peroxidation Lipid peroxidation is a process in which lipids lose hydrogen atoms due to the activity of free radicals or lipid peroxidases (58)

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Thus, the signaling mechanisms of drug-induced cell death involving ROS and peroxynitrite are flexible and can change depending on susceptibility (e.g., PUFA levels in membranes) and impairment of multi-layered antioxidant defense systems

HEP and HEP-modulators are potential candidates to reset FeRD and reverse iron-overload syndromes such as anemia and chronic kidney disease (CKD) in COVID-19 and PASC patients 27,496,497

Within mitochondria and other vulnerable cellular compartments, EGT has been shown to safeguard membrane phospholipids against lipid peroxidation and to limit oxidative injury mediated by redox-active metals, particularly iron