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Notably, coculture with L-Cn resulted in significantly reduced frequencies of IgG-secreting B cells and a tendency of reduced production of IgG in the supernatant by purified CD19 + B cells, relative to the control group ( Figure 3E )

10.1038/s41380-018-0261-8 29 DuS

doi: 10.21037/atm-21-5043 74 ChouRHChenCYChenICHuangHLLuYWKuoCSet al

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Another research using a mouse model showed that L-carnitine supplementation can inhibit the NAFLD development by decreasing TNF (receptor superfamily member 9 or CD137), CCL23 (C-C motif chemokine 23), MMP1 (matrix metalloproteinase 1), and FGF21 (fibroblast growth factor 21) in the plasma (89)

Strikingly, L-Cn up-regulated the frequency of Treg cells, along with the abundance of IL-10-producing Treg cells ( Figures 4B, C )