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Meanwhile, ATRA-NPs could significantly down-regulate the expression of PIN1, NF-B and Cyclin D1, which was comparable to the inhibitory effect of ATRA + ATO on the expression of these proteins (Fig

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648 In addition, treatment with liproxstatin-1 mitigates hypersensitivity reactions, reduces iron levels, reduces spinal cord lipid peroxidation, and prevents CCI-induced mitochondrial morphological changes, 648 suggesting that ferroptosis may be a potential therapeutic target for neuropathic pain