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5.4 Biomarker-guided treatment In the precision treatment strategy for gemcitabine resistance, biomarker guided treatment based on dynamic monitoring of RRM2 copy number based on ctDNA and multi-omics prediction models (such as the EXPLOR trial) provides a new paradigm for individualized intervention: Gemcitabine resistance, RRM2 gene copy number amplification drives resistance by accelerating deoxyribonucleotide triphosphate (dNTP) synthesis and enhancing DNA repair, while ctDNA-based liquid biopsy technology (such as ddPCR/NGS) can dynamically monitor the level of RRM2 amplification and track the evolution of resistant clones in real time

Substrate working solution, Coenzyme working solution and GSH standard solution can be stored at -20C for 2 months

It is currently unknown whether, apart from ketone body production, MCFAs per se have value as auxiliary fuels to the brain (57)

This is followed by the action of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, which catalyzes the condensation of acetoacetyl-CoA with a third acetyl-CoA molecule to form HMG-CoA [14]

Na J, Efferth T

10.1016/j.aquatox.2014.11.016 Aquat