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Upon completion of rigorous phase-3 trials, the FDA granted approval for tesamorelin therapy in 2010 in HIV-associated lipodystrophy

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Large doses of folic acid given to an individual with an undiagnosed vitamin B 12 deficiency can correct megaloblastic anemia without correcting the underlying vitamin B 12 deficiency, leaving the individual at risk of developing irreversible neurologic damage (21)

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