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In a 48-week phase 2 trial published in The New England Journal of Medicine , adults with obesity (without type 2 diabetes) receiving once-weekly subcutaneous retatrutide at the 12 mg amount achieved a least-squares mean body weight reduction of 24.2%, compared with 2.1% in the placebo group [1]

This suggests more efficient remodeling, where the peptide did not just add more material but helped organize the healing response more effectively

Despite these findings, the exact role of PON1 in AD and other neurodegenerative diseases is not fully elucidated

Most clinical improvements appear within 12-26 weeks

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