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During the 2-year study period and every three to six months, serum NFL measured with SiMoA SR-X according to manufacturers instructions [Quanterix Corporation, Lexington, MA 02,421, USA]EDSS, symbol digit modality test (SDMT) 40 , 9-hole peg test (9-HPT) 41 , and timed 25-foot walk test (T25-FW) were registered 41