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Bacterial lipopolysaccharide activates NF-B through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells

T., Ricker, J

Nevertheless, the expression of major receptors (ACE2, CD147, TMPRSS2, NRP1), facilitating the entry of SARS-CoV-2 in host cells in the nervous tissues indicates their potential role in brain invasion [21, 22]

The activation of two transcription factors, aryl hydrocarbon receptor (AhR, which is sensitive to ROS) and hypoxia-inducible factor (HIF)-1, which is responsive to the TCA metabolites succinate, were associated with an increase in IL-22 production

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Normalisation is needed to adjust for the difference in sequencing depth between samples, and to account for potential compositional biases due to the competitive nature of pooled genetic screening