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More recently, 16HBE14o-line has been utilized as a platform for CRISPR/Cas9-mediated gene editing to introduce specific rare CF-causing mutations (e.g., W1282X, N1303K)

This inflammatory state is associated with a wide range of health conditions, including metabolic syndrome, non-alcoholic fatty liver disease, type 2 diabetes, hypertension, cancer, Alzheimers and heart disease

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Silymarin also has hepatoprotective properties against acetaminophen and alcohol-induced injury in preclinical studies

Histamine stimulated cells from AD patients showed a tendency for higher 5-LO mRNA expression (4,8-fold) as compared to respective mast cells from HVs (Fig