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Cancer Res Commun

C.PuyalJ

Proper storage and handling are crucial to maintain the efficacy and safety of these injections

As for the drug-induced hypothesis, our research group has shown that melanoma cells transiently shift to a persister state, characterized by an altered metabolic profile including increased mitochondrial respiration, during treatment with various traditional chemotherapeutics 33

Lopez N, Tormo C, De Blas I, Llinares I, Alom J

In mitochondria, electron leakage at Complexes I and III generates superoxide (O), a process often exacerbated by mutations in assembly factors like cytochrome c oxidase assembly factor 1 (COA1) or cytochrome c oxidase assembly factor 18 (COX18) [16, 17]