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Abbreviations FDP: Felodipine CMC: Carboxymethyl cellulose DoE: Design of experiments TBA: Thio barbituric acid EA: Edge activator LC: Loading capacity EE: Entrapment efficiency ZP: Zeta potential PD: Polydispersity index PS: Particle size J max : Maximum flux ER: Enhancement ratio SLW: SL-loaded wafers TAC: Total antioxidant capacity NO: Nitric oxide NBT: Nitro blue tetrazolium ANOVA: Analysis of variance SL: Spanlastics DI: Deformability index LDLs: Low-density lipoproteins TCA: Thiobarbituric acid ROS: Reactive oxygen species FDP-SLW: Felodipine- Spanlastics loaded wafer C max : Peak plasma concentration Ke: Elimination rate Ka: Absorption rate constant Fr: Relative bioavailability References Abd El Azim, H., Nafee, N., Ramadan, A

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